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KMID : 0358320080490030208
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Korean Journal of Urology
2008 Volume.49 No. 3 p.208 ~ p.214
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Radiofrequency Ablation of Unilateral Kidney VX2 Tumors in the Rabbit Model
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Gil Myung-Cheol
Ha Jung-Min
Yoon Seong-Kuk
Chung Jae-Il
Jung Se-Il
Yoon Jin-Han
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Abstract
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Purpose: The aim of this study was to evaluate the effectiveness and indication of radiofrequency ablation(RFA) using renal VX2 tumors by implantation of VX2 tumor cells under the renal capsule in rabbits.
Materials and Methods: Ten rabbits were injected with 30-40?l VX2 tumor cells(1.2x107 viable cells/ml) under the renal capsule of the right kidney by right subcostal incision. On the 14th day after the tumor cells were implanted, we checked for the development of renal tumors, and the sizes and shapes(exophytic or central) of the tumors by the use of computed tomography. We performed RFA in the renal VX2 tumors with a 17G StarBurst electrode through kidney exposure. After the first and third day following RFA, renal function was checked. On the third day, we performed CT and harvested the kidneys for gross and microscopic evaluation.
Results: We confirmed the development of renal VX2 tumors in nine cases. Tumor shapes were exophytic in seven cases and central in two cases; the mean size of the tumors was 2.1 cm(range, 1.1-3.8cm). In all tumors, RFA was performed. From the use of enhanced CT after RFA on the third day, all of the lesions treated with RFA showed no enhancement. From the pathological findings, coagulative necroses were seen on all of the lesions treated with RFA. The necrotized tumor size after RFA was not different statistically as measured by CT and a pathological examination (p=0.833)
Conclusions: In centrally located renal tumors, we experienced thermal injury in pelvocalyceal systems. RFA is an effective method for nephron sparing surgery as the tumor cells completely disappear and there is preserved renal function and the procedure is easy to apply. We suggest that the RFA method for exophytic renal tumors is more effective than other procedures. (Korean J Urol 2008;49:208-214)
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KEYWORD
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Catheter ablation, Radiofrequency, Kidney neoplasms, Rabbits, VX2
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